ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES LEVELS IN THE PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER DURING ACUTE ATTACK
1 Atatürk Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Erzurum  
2 Atatürk Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı Erzurum  
3 Atatürk Üniversitesi Tıp Fakültesi Nefroloji Bilim Dalı, Erzurum  
Eurasian J Med 2001; 33: 7-9

Key Words: Familial Mediterrenean fever, Antineutrophil cytoplasmic antibodies (ANCA)
Abstract

Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed at lysosomal constituens of leucocytes, with two major immunufluoresence stainig patterns: cytoplasmic (c-ANCA), and perinuclear (p-ANCA). ANCA can be found mainly pauci-immune necrotising vasculitis and other inflammatory disease. We tested the prevalance of antineutrophil cytoplasmic antibodies during acute attacks in 18 patients with familial Mediterranean fever (FMF). There was a patient positivity among the FMF patients. There were no ANCA positivity among the 20 healty control group. There were no statisticaly signification between FMF patients and healty control group (p=0.474). We suggest that FMF, perhaps as a consequence of impaired control of inflammatory responses to vasculitis. The role of antineutrophil cytoplasmic antibodies in the inflammation pathogenesis of FMF patients is not clear.

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