ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
THE RELATIONSHIP BETWEEN LEPTIN LEVELS AND WEIGHT LOSS IN PATIENTS WITH MALIGN TUMORS
1 Atatürk University Medical Faculty, Department of General Internal Medicine (FE), Atatürk University Medical Faculty, Department of Endocrinology and Metabolism (İÇ, HÇ, NU), Atatürk University Medical Faculty, Department of Biochemistry (LY)  
2 Atatürk Üniversitesi Tıp Fakültesi Biyokimya Anabİlim Dalı  
Eurasian J Med 2005; 37: 61-65

Key Words: Leptin, Malign tumor, Weight loss
Abstract

Leptin, a product of the obese (ob) gene, produced in adipose tissue, is related to the control of body weight and energy expenditure. This study was carried out to demonstrate the relationship between body mass index and leptin levels in patients with solid malign tumor and to find out whether there was any difference in leptin levels after the weight loss in those patients. The study included 30 patients with confirmed solid malign tumor by biopsy. But, 18 patients completed the study. We found out a significant correlation between BMI values and leptin levels at the beginning (r= 0.796, p<0.01). Similarly, there was a significant correlation between the values of BMI and leptin levels after the weight loss (r=0.808, p<0.01). We concluded that decrease in the leptin levels occured after lost of weight is more likely to develop due to a decrease in fat mass in patients with solid malign tumor.

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