ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Biological Markers of Acute Lung Injury After Thoracotomy
1 Atatürk Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Erzurum  
Eurasian J Med 2006; 38: 107-112

Key Words: Biological marker, Injury, Thoracotomy, Trauma
Abstract

 

Objective: There are many etiological factors for ARDS and ALI. In our study, we studied whether operative manuplations can cause ARDS or ALI or not.

 

Materials and Methods: Total 113 patient, electively operated at General Surgery and Thoracic Surgery Departments, hospitalized for thoracal trauma with pulmonary contusion and mechanically ventilated at the intensive care unit were selected for the study. Serum albumin, CRP, procalcitonin, alpha-1-antitripsin, ESR, ceruloplasmin, haptoglobulin, white blood cell, D-dimer, fibrinogen, and arterial blood gases of patients were analysed and compared.

Results: There were statistically significantly decreases in the serum albumin levels and PO2/FiO2ratio at arterial blood gas analysis in the patients with lung injury due to surgery. There were significant increases in the CRP and WBC level in the same group of patients. In the mechanically ventilated patient group, we observed that these parametrial changes increased with the prolonged medical tretment follow-up.

Conclusion: An increase in ALI level was directly proportional to the surgical manuplation in the patients with thoracotomy. We concluded that the decrease in the level of serum albumin and PO2/ FiO2 ratio and the increase in the level of CRP and white blood cell count may be used as biological markers of the diagnosis and treatment of ALI.

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