ISSN 1308-8734 | E-ISSN 1308-8742
Review
The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity
1 Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
Eurasian J Med 2012; 44: 43-45
DOI: 10.5152/eajm.2012.09
Key Words: Adrenergic receptor, Estrogen, Luteinizing hormone, Oxidant, Ulcer
Abstract

 

Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of gastric ulcer formation have been reported to act by blocking alpha-2 adrenergic receptors, whereas drugs possessing anti-ulcer activity have been shown to ensure gastric protection by stimulating the alpha-2 adrenergic receptors. The data derived from the literature indicate the likelihood that any drug or substance selectively stimulating the alpha-2 adrenergic receptors may possess anti-ulcer activity. 

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