ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
The Significance of Serum Transferrin Receptor Levels in the Diagnosis of the Coexistence of Anemia of Chronic Disease and Iron Deficiency Anemia
1 Department of Hematology, Okmeydani Education and Research Hospital, Istanbul, Turkey  
2 Department of 4. Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey  
3 Department of Hematology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey  
4 Department of Hematology, Fatih University School of Medicine, Ankara, Turkey  
5 Department of Hematology, Mustafa Kemal University School of Medicine, Hatay, Turkey  
Eurasian J Med 2011; 43: 9-12
DOI: 10.5152/eajm.2011.02
Key Words: Anemia of chronic disease, Iron deficiency anemia, Serum transferrin receptor level


Objective: Iron deficiency anemia is the most common cause of microcytic anemia throughout the world. Ferritin levels are good indicators of iron stores; however, levels may increase irrespective of iron stores in cases of chronic disease. Therefore, it is difficult to diagnose iron deficiency anemia coexisting with anemia of chronic disease.

Materials and Methods: To determine the level of transferrin receptor in subjects, 30 patients with iron deficiency anemia, 30 patients with anemia of chronic disease and 30 patients with both diseases were included in the study.

Results: Mean serum transferrin receptor levels were 5.99±2.98 mg/L in the iron deficiency anemia group, 1.90±1.15 mg/L in the anemia of chronic disease group and 3.07±0.90 mg/L in the combination group. Comparing groups with each other revealed significant differences (p<0.05).

Conclusion: It is concluded that the assessment of serum transferrin receptor levels is a useful method for the diagnosis of iron deficiency anemia in patients.

Key Words
Author’s Corner
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