ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Trace Element Levels in Patients with Familial Mediterranean Fever
1 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
2 Department of Nephrology, Faculty of Medicine, Atatürk University, Erzurum, Turkey  
3 Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
Eurasian J Med 2011; 43: 79-82
DOI: 10.5152/eajm.2011.18
Key Words: Copper, Familial Mediterranean fever, Selenium, Trace elements, Zinc


Objective: Although the genetic etiology of familial Mediterranean fever (FMF) is known, limited information is available regarding the regulation of inflammation during attack-free periods. The aim of this study was to determine the alterations in serum copper (Cu), zinc (Zn) and selenium (Se) levels that may be associated with inflammation during attack-free periods in FMF patients.

Materials and Methods: This study included 33 patients with FMF and 30 healthy volunteers. Erythrocyte sedimentation rate (ESR), the serum C-reactive protein (CRP) level and serum levels of Cu, Zn and Se in FMF patients and healthy volunteers were assessed by the atomic absorption spectrophotometry method.

Results: ESR and serum CRP levels and serum Cu and Zn levels were similar between patients with FMF during an attack-free period and healthy controls (p>0.05). Serum Se levels in the patient group were significantly higher than in the control group (p<0.05).

Conclusion: Our study shows that levels of trace elements in serum are variable in patients with FMF during attack-free periods. Serum Se concentrations may at least in part contribute to the subclinical inflammation in FMF patients during attack-free periods. However, further studies are necessary to confirm this result.

Key Words
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