ISSN 1308-8734 | E-ISSN 1308-8742
Case Report
Cerebral Venous Thrombosis and Pulmonary Embolism with Prothrombin G20210A Gene Mutation
1 Department of Pulmonology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey  
2 Department of Infectious Diseases, Kahramanmaras Yenisehir State Hospital, Kahramanmaras,Turkey  
3 Department of Neurology, Kahramanmaras Sutcu Imam University, Kahramanmaras,Turkey  
Eurasian J Med 2010; 42: 38-39

Key Words: Prothrombin G20210A gene mutation, pulmonary embolism, cerebral venous thrombosis

A 25-year-old man presented with symptoms of syncope, cough, headache and hemoptysis. Cranial MR and venography showed thrombus formation in the right transverse sinus and superior sagittal sinus. Computed tomographic pulmonary angiography (CTPA) showed an embolic thrombus in the right pulmonary truncus and lung abscess. The patient was young, and there were no signs of lower extremity deep venous thrombosis or other major risk factors for pulmonary embolism (PE) including cardiac anomaly. The only risk factor we were able to identify was the presence of the prothrombin G20210A gene mutation. Anticoagulant treatment with oral warfarin (10 mg daily) and imipenem (4X500 mg) was started. The patient was hospitalized for antibiotic and anticoagulation therapies for three weeks and was discharged on lifelong treatment with warfarin (5 mg daily).

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