ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats
1 Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum  
2 Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey  
3 Fatih Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Ankara  
4 Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey  
Eurasian J Med 2013; 45: 1-6
DOI: 10.5152/eajm.2013.01
Key Words: Catalase, glutathione peroxidase, L-carnitine, Liver, Malondialdehyde, Myeloperoxidase

Objective: The present study was designed to investigate the dose-dependent protective effect of L-carnitine (LC) on thyroid hormone-induced oxidative stress in rat liver tissue.

Materials and Methods: Twenty-one male Sprague Dawley rats were divided into four groups: control, hyperthyroidism, hyperthyroidism plus L-carnitine 100, and hyperthyroidism plus L-carnitine 500. Hyperthyroidism was induced in rats by injecting 250 μg of L-thyroxine/kg body weight/day for twenty consecutive days. The activities of catalase (CAT), glutathione peroxidase (GPX) and myeloperoxidase (MPO) and the level of malondialdehyde (MDA) were measured in liver homogenates.

Results: The liver CAT, GPX and MPO activities were significantly lower in the hyperthyroid rats than in the control group. Treating hyperthyroid rats with both low-dose (100 mg/kg) and high-dose (500 mg/kg) L-carnitine for 10 days resulted in a marked increase in the activities of the antioxidant enzymes in the liver tissue.

Conclusion: The present study indicates that the low-dose L-carnitine application was sufficient to prevent L-thyroxine-induced oxidative stress in rat livers.

Key Words
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