ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Relationship between Serum Gamma-glutamyl Transferase Levels with Ascending Aortic Dilatation
1 Department of Cardiology, Ordu University Faculty of Medicine, Ordu, Turkey  
2 Department of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey  
3 Department of Family Medicine, Ordu University Faculty of Medicine, Ordu, Turkey  
4 Department of Internal Medicine, Ordu University Training and Research Hospital, Ordu, Turkey  
5 Department of Cardiology, Ataturk University Faculty of Medicine, Erzurum, Turkey  
6 Department of Emergency Medicine, Ataturk University Faculty of Medicine, Erzurum, Turkey  
Eurasian J Med 2014; 46: 89-95
DOI: 10.5152/eajm.2014.22
Key Words: Gamma-glutamyl transferase, aortic dilatation, oxidative stres
Abstract

Objective: Increased serum gamma-glutamyl transferase levels (GGT) have been shown to directly promote oxidative stress. Previous studies have shown the relationship between the dilatation of the ascending aorta and oxidative stress. This study was designed to examine the relationship between serum GGT concentrations with dilatation of the ascending aorta.

 

Materials and Methods: Ninety patients with ascending aortic dilatation and 90 age-sex-matched patients without aortic dilatation were included in the study. The patients were evaluated by a complete transthoracic echocardiographic examination including measurement of the aortic dimensions, where a diameter of 3.7 cm and above was accepted as ascending aortic dilatation. Serum GGT concentration was measured in all patients.

 

Results: In the group with aortic dilatation, HT frequency, serum uric acid, hs-CRP and GGT levels, the LV mass index, and the left atrial volume index were found to be higher than the control group. The logistic regression analysis showed that only HT frequency (OR:1.23, 95% CI 1.11-1.35, p value: 0.02), the LA volume index (OR: 1.34, 95% CI 1.21±1.4, p:0.005) and serum GGT levels (OR: 1.12, 95% CI 1.01±1.20, p:0.03) were found to be independent predictors. There was a significant correlation between serum GGT levels and ascending aortic diameter (r: 0.268, p<0.001). In the ROC curve analysis, AUC was 0.659 (0.580±0.738) for a 23.5 serum GGT cut-off value (64% sensitivity and 53% specificity).

 

 

Conclusion: We found that serum GGT concentration was significantly associated with ascending aortic dilatation. Large epidemiological studies are required to correlate the findings from this study with clinical outcome. 

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