ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis
1 Division of Nephrology, Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey  
2 Division of Gastroenterology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey  
3 Division of Rheumatology, Department of Internal Medicine, Akdeniz University Medical School, Antalya, Turkey  
Eurasian J Med 2015; 47: 21-25
DOI: 10.5152/eajm.2014.0016
Key Words: Cirrhosis, Child Pugh classification, von Willebrand factor

Objective: Von Willebrand factor (vWF) is a mediator that increases endotoxemic medium like in cirrhosis. In this study we evaluated the association of serum VWF antigen (Ag) level with the stage of cirrhosis (according to Child-Pugh classification).


Materials and Methods: We included 82 cirrhotic patients (Female/Male (F/M): 26/56) and 86 healthy subjects (F/M: 44/42) in the study. Ages of the both groups of patients were not different (P= 0.095). We excluded possible other reasons that may cause VWF level increase. Diagnosis of cirrhosis was made on the basis of biopsy in 7 patients and with clinical and laboratory parameters in 75 patients. VWF Ag level was determined by immunoturbidimetric test. The stage of cirrhosis was defined with Child-Pugh classification. Data were analysed by using Statistical Package for the Social Sciences (SPSS) 10.0 software program.


Results: VWF Ag level was significantly higher in cirrhotic patients compared to control group (220±90 and 87±38, P<0.001, respectively). We observed significant increase of VWF Ag level with the increasing stages of cirrhosis according to Child-Pugh score (VWF Ag level for Child A-B-C 156.4±54/215±45/284.8±93, respectively; P values for Child A-B/A-C/B-C; <0.001/<0.001/0.006, respectively).


Conclusion: Serum VWF Ag level increases in cirrhotic patients and this is more pronounced with higher stages of cirrhosis. 

Key Words
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