ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis
1 Department of Otorhinolaryngology, Military Medical Academy School of Medicine, Belgrade, Serbia  
2 Institute for Pathology, Military Medical Academy School of Medicine, Belgrade, Serbia  
3 Institute for Pharmacy, Military Medical Academy School of Medicine, Belgrade, Serbia  
4 Institute for Medical Research, Division of Clinical and Experimental Immunology, Military Medical Academy School of Medicine, Belgrade, Serbia  
Eurasian J Med 2017; 49: 178-182
DOI: 10.5152/eurasianjmed.2017.17203
Key Words: Allergic rhinitis, chemokines, eosinophils, glucocorticoids, inflammation mediators
Abstract

Objective: Eotaxin-2 and regulated on activation normal T cell expressed and secreted (RANTES) are involved in the eosinophil trafficking in patients with persistent allergic rhinitis (PAR). Clara cell protein 16 (CC16) is an anti-inflammatory protein mainly produced by the epithelial non-ciliated Clara cells. The aim of this study was to investigate the production of CC16 and chemokines eotaxin-2 and RANTES in nasal mucosa of patients with PAR.

 

Materials and Methods: Twenty-one PAR patients and 20 healthy participants were included. CC16, eotaxin-2, and RANTES concentrations were measured in nasal secretions. PAR patients were administered fluticasone furoate nasal spray (220 μg daily for 14 days). We performed nasal cytology, symptom score assessment, and inflammatory mediator detection before and after the therapy.

 

Results: The level of CC16 in patients with PAR was lower than in the healthy subjects (p=0.023). The eosinophil counts and local concentrations of eotaxin-2 and RANTES were higher in patients with PAR in comparison with controls (p=0.008, p=0.001, p=0.031, respectively). We also found a negative correlation between the CC16 and eotaxin-2 levels in nasal secretions of PAR patients (r=−0.492, p=0.023). After corticosteroid therapy, the patients with PAR had lower nasal symptoms, eosinophil counts, eotaxin-2, and RANTES levels and higher levels of CC16 (p<0.001 for all parameters).

 

Conclusion: Our results suggest the presence of a negative correlation in production of CC16 and eotaxin-2 in nasal mucosa of patients with PAR. Intranasal corticosteroids have a suppressive effect on mucosal eosinophilic inflammation and a stimulating effect on local CC16 production.

 

Cite this article as: Perić A, Špadijer Mirković C, Vukomanović Đurđević V, Perić AV, Vojvodić D. Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis. Eurasian J Med 2017; 49: 178-82.

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