Oxidative stress and inflammation are held responsible for the pathogenesis of epilepsy. Prolidase is known to have an extremely important role for proline recycling in collagen synthesis. Higher proline levels have been shown to increase oxidative stress. Furthermore, prolidase activity is known to be associated with inflammation during fibrotic process. No study has yet investigated the relationship between epilepsy and prolidase enzyme activity (PEA). In this study, we aimed to contribute to the existing literature by assessing postictal PEA levels, which are known to be correlated to inflammation and oxidative stress, in order to determine whether PEA levels may be used as a biomarker for the disorder. This study included patients with epilepsy who presented to emergency department within first six hours after a seizure. The epileptic group included 27 patients (16M, 11F) and the control group 31 healthy individuals (11M, 20F). The mean age of the epilepsy group (n=27) was 43.1±20.2, and the healthy control group (n=31) 51.9±21 years. Serum PEA levels were 1171.9 ± 343.3 in the epileptic group and 1137.1 ± 295.6 in the control group. There were no significant differences between two groups. (p> 0.05) Our study results suggest that, although PEA is an enzyme associated with oxidative stress and inflammation, it is still not an ideal biomarker for epileptic patients. This study is an important one as it investigated PEA in patients with idiopathic epilepsy for the first time.

Cite this article as: Ozozen Ayas Z, Kotan D, Akdogan M, Gunel ME. Serum prolidase enzyme activity level: Not a predictive biomarker for epilepsy. Eurasian J Med 2018; DOI: 10.5152/eurasianjmed.2018.18183