ISSN 1308-8734 | E-ISSN 1308-8742
Original Article
The Relationship between 18-FDG-PET/CT and Clinicopathologic Features, Pathologic Response in Patients with Locally Advanced Breast Cancer
1 Department of Medical Oncology, Dr Ersin Arslan Training and Research Hospital, Gaziantep, Turkey  
2 Department of Medical Oncology, Atatürk University School of Medicine, Erzurum, Turkey  
3 Department of Medical Oncology, Erzincan University School of Medicine, Erzincan, Turkey  
Eurasian J Med ; : -
DOI: 10.5152/eurasianjmed.2018.18036
Key Words: Breast cancer, 18F-FDG, neoadjuvant chemotherapy.
Abstract

Objective: We investigated the relation between maximum standardized uptake value (SUVmax) of whole body positron emission tomography/computed tomography (PET/CT) performed before treatment and demographical and histopathological features in locally advanced breast cancer(LABC)  and the role of PET/CT in evaluation of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC).


Materials and Methods
: 51 LABC patients who have received NAC in our center between 2011 and 2015 were analyzed retrospectively. Basal PET/CT was performed in all patients before NAC. SUVmax levels and demographical and histopathological results were compared. The relation between SUVmax values after NAC and pathological responses were evaluated.


Results
: Mean age of the patients was 49 (32-69). PET/CT performed after NAC showed complete response in 20 patients (39.2%), partial response in 28 patients (54.9%), stable disease in 2 patients (3.9%), and progressive disease in one patient (2%). There was no significant difference between mean SUVmax values of the patients according to age (>50, ≤50), menopausal status, tumor localization, clinical stage, and grade. Mean SUVmax value was higher in triple negative group than HER2 positive group and luminal group. There was significant difference in SUVmax values between the group that pCR achieved after NAC and the group that not pCR (SUVmax value for breast 2.92 vs 0.30, p=0.01, SUVmax value for axilla 1.5 vs 0.0, p=0.02).


Conclusion
: SUVmax values are not related to demographical features. There was a significant relationship between pCR and SUVmax values after NAC. PET/CT could be useful in evaluation of patients to predict biologic characteristics of tumors.apy
(NAC).

 


Cite this article as
:  Yildirim N, Simsek M, Aldemin MN, Bilici M, Tekin SB. The Relationship between 18-FDG-PET/CT and Clinicopathologic Features, Pathologic Response in Patients with Locally Advanced Breast Cancer. Eurasian J Med 2018; DOI: 10.5152/eurasianjmed.2018.18036.

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