The Eurasian Journal of Medicine
Original Article

Comparison of Serum Adropin Levels in Patients with Diabetes Mellitus, COVID-19, and COVID-19 with Diabetes Mellitus


Department of Anesthesiology and Reanimation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey


Department of Health Services, Bayburt University Vocational School, Bayburt, Turkey


Department of Internal Medicine, Atatürk University Faculty of Medicine, Erzurum, Turkey


Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

Eurasian J Med 2022; 54: 197-201
DOI: 10.5152/eurasianjmed.2022.22128
Keywords : Adropin, COVID-19, DM, d-dimer, CRP
Read: 1060 Downloads: 380 Published: 01 June 2022

Objective: In the present study, the relationship between a poor prognosis and adropin levels in diabetic patients with coronavirus disease 2019 was investigated by measuring serum adropin levels and levels of D-dimer, C-reactive protein, and ferritin, which are considered prognostic factors for coronavirus disease 2019.

Materials and Methods: Hundred volunteer participants treated in the Erzurum Regional Training and Research Hospital were included in this study. Serum adropin levels were measured by enzyme-linked immunosorbent assay. The relationship between serum adropin level and C-reactive protein, ferritin, and D-dimer levels was analyzed by correlation analysis.

Results: The participants’ serum adropin levels differed between the groups (P = .0007). The control group had the highest adropin levels among groups. The lowest adropin levels were in the COVID + diabetes mel- litus group. Adropin levels of diabetes mellitus, COVID, and diabetes mellitus+COVID groups were sig- nificantly decreased when compared to the control (P < .05). There was a significant negative correlation between adropin and C-reactive protein, D-dimer, and ferritin.

Conclusion: Adropin can be used as an auxiliary biomarker, a prognostic factor in the early management of coronavirus disease 2019 patients with diabetes mellitus. We think that our study will guide future studies conducted in this field.

Cite this article as: Aydın P, Karabulut Uzunçakmak S, Tör İH, Bilen A, Özden A. Comparison of serum adropin levels in patients with diabetes mellitus, COVID-19, and COVID-19 with diabetes mellitus. Eurasian J Med. 2022;54(2):197-201.

EISSN 1308-8742