ISSN 1308-8734 | E-ISSN 1308-8742
1 Department of Pediatric Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey  
2 Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey  
3 Department of Microbiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey  
4 Department of Biochemistry, Reyhanlı State Hospital, Hatay, Turkey  
Eurasian J Med ; : -

Abstract

Objective: The aim of this study was to investigate the protective effects of combined use probiotic strains on developing bacterial translocation, liver and intestinal tissue damage due to biliary obstruction in rats.

 

Material and Methods: 3 groups each consisting of 10 rats were created in the study. Group 1 (sham group), group 2 (obstructive jaundice), group 3 (obstructive jaundice+probiotic). The group 1 and group 2 were given 1 cc physiological saline solution by oral gavage twice a day, the group 3 was given the probiotic solution that included Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Enterococcus faecium and Bifidobacterium longum microorganisms, by oral gavage twice a day.

 

Results: The markers of liver damage, were also found to be significantly improved (p˂0.05) in the treatment group (group 3). Compared with group 2 and group 3 in terms of liver histology, the damage was found to be significantly more severe in the group 2 (p <0.01). From the point of ileal villous depth and ileal inflammation parameters, the pathology was found to be significantly more severe in the group 2 than in the group 3 (p <0.05). In blood, spleen and MLN cultures, the group 2 showed a microbiological growth rate of 33.8% to 58.8%, whereas the group 3 showed a microbiological growth rate of 14.3% to 28.6%. This reduction was evaluated to be statistically significant (p˂ 0.05).

 

Conclusions: Our study showed that the combined use of probiotic in bile duct obstructions reduced the bacterial translocation and alleviated the pathological changes arising in the liver and terminal ileum histology.

 

You may cite this article as: Çelikkaya ME, Akçora B, Hakverdi S, Özer B, Ulutaş KT, Duran N. The Effects Of Probiotic Use On Bacterial Translocation In Created Rat Model Of Biliary Obstruction. Eurasian J Med 2019; DOI: 10.5152/eurasianjmed.2019.18426.

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