Organophosphate and Carbamate Toxicity

The insecticides most often implicated in systemic diseases are organophosphates and carbamates. These compounds are too toxic to exposure. Their effect mechanism includes inhibition of cholinesterase enzyme in nervous system. Symptoms and findings depend on the equilibrium between the nicotinic and muscarinic receptors. Therapy of organophosphate and carbamate poisoning includes supportive treatment, decontamination procedure, prevention of absorption and antidote administration.