G6PD Enzym in Hemolytic Anemia

Glukoz-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) is called “ubiquitous” since it is the key enzyme of Pentoz Phosphate pathway and found in various living populations. It is also known as the “housekeeping” enzyme as it is vital for life. G6PD deficiencies have been found to exist in almost 400 million people around the world. In turn, the enzyme displays nearly 400 variants, showing different kinetic properties. The deficiency of G6PD may result in hemolytic anemia due to drug toxication, infections during the neonatal period, consumption of beans and stress conditions. The degree of hemolysis depends on cases. Erythrocyte enzymopathies are a heterogeneous group; it is, therefore, important to know whether there is deficiency of G6PD or not.