The Levels of Serum C-Reactive Protein, Beta 2 Microglobulin, Ferritin, Lactate Dehydrogenase and Some Specific Proteins in Patients with Non-Hodgkin’s Lymphoma Before and After Treatment

Objective: The aim of this study was to measure serum C reactive protein, β2 microglobulin, ferritin, lactate dehydrogenase, complement 3, complement 4, immunoglobulin A, immunoglobulin M, immunoglobulin G and transferrin levels in patients with Non-Hodgkin Lymphoma before and after treatment, and to determine whether any differences occur with treatment, investigate relationship between these parameters and systemic symptoms, and to determine whether they could be used as tumor markers.

Materials and Methods: The parameters listed above were studied before and after treatment in sera of 27 patients with the diagnosis of Non-Hodgkin Lymphoma who admitted to our department. Of the patients, 10 [37%] were females and 17 [63%] were males. Mean age was 57.7 ± 16.5 [19-82] years. The subjects were newly diagnosed and treatment.

Results: Post-treatment serum ferritin and CRP levels were found to be significantly decreased in patients with NHL compared to pre-treatment levels [p=0.009 and p=0.015, respectively]. In addition, ferritin levels measured before treatment were significantly lower in subjects with B symptoms than those without B symptoms [p=0.02]. IgA levels of patients with B symptom were significantly increased compared to those without B symptoms following treatment [p=0.03].

Conclusions: We are in the opinion that serum ferritin and CRP parameters may be used as tumor markers and may be indicators in the efficacy evaluation of treatment in Non-Hodgkin's Lymphoma.