IgE-Mediated Reaction to Metamizole: Evaluation of a Patient with Severe Anaphylaxis

Metamizole, a non-steroidal anti-inflammatory drug with weak anti-inflammatory and spasmolytic effects, is used as an analgesic and antipyretic agent. Many adverse reactions to metamizole, such as early or late-onset systemic reactions and bone marrow suppression, have been identified. In this report, we present a case of systemic reaction after the application of parenteral metamizole (Novalgin® ampoule; Sanofi Aventis, İstanbul, Turkey) and discuss the mechanism underlying the reaction.