Published In
The Eurasian Journal of Medicine
Volume 57 · Issue 1 · January 2025
Pages: 1-5
History
Published Online: April 21, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2025 The Eurasian Journal of Medicine
Tyler Walburn
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Yetkin Tuaç
Department of Statistics, Ankara University Faculty of Science, Ankara, Türkiye
Çağdaş Aktan
Department of Medical Biology, Bandırma Onyedi Eylül University Faculty of Medicine, Balıkesir, Türkiye
Okan Argun
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Luke W. Chen
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
David D. Yang
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Shalini Moningi
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Jonathan E. Leeman
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Peter F. Orio
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Paul L. Nguyen
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Anthony V. D’Amico
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Mutlay Sayan
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Walburn, T., Tuaç, Y., Aktan, Çağdaş, Argun, O., Chen, L. W., Yang, D. D., … Sayan, M. (2025). Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer. The Eurasian Journal of Medicine, 57(1), 1–5. https://doi.org/10.5152/eurasianjmed.2025.25804
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Abstract
Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood.
Methods: The individual patient data from the The Cancer Genome Atlas (TCGA) database following radical prostatectomy was retrospectively examined. A predefined statistical analysis was conducted to evaluate the potential association between CP4 and progression-free survival (PFS).
Results: Of the 135 patients examined, CP4 was present in 66 (48.9%). Median follow-up was 45.93 months (interquartile range: 22.87, 80.10). Cribriform pattern 4 was associated with a significantly reduced PFS (subdistribution hazard ratio, 1.99; 95% CI, 1.01-3.92; P = .045) following adjustment for covariates.
Conclusions: The presence of CP4 in high-risk Gleason 8-10 PC portends worse PFS. Further studies are warranted to fully understand its implications in risk stratification and post-operative management of PC.
Cite this article as: Walburn T, Tuac Y, Aktan C, et al. Impact of cribriform pattern on progression-free survival after radical prostatectomy in gleason score 8-10 prostate cancer. Eurasian J Med. 2025; 57(1), 0804 doi: 10.5152/eurasianjmed.2025.25804.
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Article Info
Published In
Journal
The Eurasian Journal of Medicine
Volume / Issue
Volume 57 · Issue 1 · January 2025
Pages
1-5
History
Published Online
April 21, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2025 The Eurasian Journal of Medicine
Affiliations
Tyler Walburn
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Yetkin Tuaç
Department of Statistics, Ankara University Faculty of Science, Ankara, Türkiye
Çağdaş Aktan
Department of Medical Biology, Bandırma Onyedi Eylül University Faculty of Medicine, Balıkesir, Türkiye
Okan Argun
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Luke W. Chen
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
David D. Yang
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Shalini Moningi
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Jonathan E. Leeman
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Peter F. Orio
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Paul L. Nguyen
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Anthony V. D’Amico
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Mutlay Sayan
Department of Radiation Oncology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Cite this Article
Walburn, T., Tuaç, Y., Aktan, Çağdaş, Argun, O., Chen, L. W., Yang, D. D., … Sayan, M. (2025). Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer. The Eurasian Journal of Medicine, 57(1), 1–5. https://doi.org/10.5152/eurasianjmed.2025.25804
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