Evaluation of the Correlation of Serum Copeptin Levels Patients Diagnosed with Gastrointestinal System Bleeding with the Stage of Hemorrhagic Shock

Background: The relationship between serum copeptin (CPT) levels and the stage of hemorrhagic shock and the need for fluid/blood replacement in patients with gastrointestinal system (GIS) bleeding has not yet been clearly established. Therefore, this study was planned to evaluate the relationship between serum CPT levels and the stage of hemorrhagic shock and the need for fluid/blood replacement in patients diagnosed with GIS bleeding.

Methods: This prospective, single-center, observational study was conducted on a total of 90 patients; 43 of these were patients with GIS bleeding, and 47 were in the control group (peptic ulcer). Serum CPT levels were measured using the enzyme-linked immunosorbent assay method. Stages of hemorrhagic shock were determined according to the Advanced Trauma Life Support 11th edition. Hemoglobin, hematocrit, meancorpuscular volume, international normalized ratio, lactate, base deficit, and replacement needs were determined and recorded.

Results: While there was a statistically significant difference between serum CPT levels and the blood parameters studied in patients with GIS bleeding, only the stages of hemorrhagic shock did not statistically affect CPT levels. Increased fluid and blood product replacement was observed in advanced shock stages.

Conclusion: Elevated serum CPT levels in patients with GIS bleeding may be a prognostic biomarker reflecting the severity of the disease. However, it is not sufficient on its own for determining hemorrhagic shock stages and predicting replacement needs.

Cite this article as: Çalbay A, Çalbay MM, Akgöl Gür ST, Bayramoğlu A, Öztürk N, Albayrak B. Evaluation of the correlation of serum copeptin levels patients diagnosed with Gastrointestinal System bleeding with the stage of hemorrhagic shock. Eurasian J Med. 2026, 58(4), 1248, doi: 10.5152/ eurasianjmed.2026.251248